| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 38331851 | Efficacy and safety of peppermint oil for the treatment in Japanese patients with irritable bowel syndrome: a prospective, open-label, and single-arm study |
| Probiotics | 📋 | ✍ | ⛔ | | 38479936 | Efficacy and safety of probiotics in irritable bowel syndrome: A systematic review and meta-analysis |
| Psyllium | 📋 | ✍ | ⛔ | | 35060943 | A Randomized Pilot Study to Compare the Effectiveness of a Low FODMAP Diet vs Psyllium in Patients With Fecal Incontinence and Loose Stools |
| Curcumin | 📋 | ✍ | ⛔ | | 38674895 | The Possible Synergistic Pharmacological Effect of an Oral Berberine (BBR) and Curcumin (CUR) Complementary Therapy Alleviates Symptoms of Irritable Bowel Syndrome (IBS): Results from a Real-Life, Routine Clinical Practice Settings-Based Study |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38445822 | Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study |
| Berberine | 📋 | ✍ | ⛔ | | 38674895 | The Possible Synergistic Pharmacological Effect of an Oral Berberine (BBR) and Curcumin (CUR) Complementary Therapy Alleviates Symptoms of Irritable Bowel Syndrome (IBS): Results from a Real-Life, Routine Clinical Practice Settings-Based Study |
| Kiwifruit | 📋 | ✍ | ⛔ | | 37126812 | In persons with constipation or IBS-C, kiwifruit vs. psyllium increased spontaneous bowel movements |
| Ginger | 📋 | ✍ | ⛔ | | 38338475 | Ameliorative Effects of Zingiber officinale Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function |
| Food | 📋 | | | | 37094910 | Role of Low-FODMAP diet in functional dyspepsia: "Why", "When", and "to Whom" |
| Aloe Vera | 📋 | ✍ | ⛔ | | 38328440 | The Potential Application of Aloe Barbadensis Mill. as Chinese Medicine for Constipation: Mini-Review |
| Zinc | 📋 | ✍ | ⛔ | | 35747897 | Effect of Zinc Supplementation in Children Less Than 5 Years on Diarrhea Attacks: A Randomized Controlled Trial |
| Atractylodes | 📋 | ✍ | ⛔ | | 38230827 | Structure of crude polysaccharides from Atractylodes lancea rhizome and treatment of diarrhea owing to spleen deficiency through intestinal flora |
| Melatonin | 📋 | ✍ | ⛔ | | 37098505 | The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double-blinded placebo-controlled trial study |
| Rhubarb | 📋 | | ⛔ | | 38073524 | Rhubarb extract rebuilding the mucus homeostasis and regulating mucin-associated flora to relieve constipation |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38195431 | Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial |
| Medicinal Plants | 📋 | | | | 36107498 | Complementary and alternative medicine for functional dyspepsia: An Asian perspective |
| Patchouli | 📋 | ✍ | ⛔ | | 37513952 | Probiotic Formulations Containing Fixed and Essential Oils Ameliorates SIBO-Induced Gut Dysbiosis in Rats |
| Astragalosides | 📋 | ✍ | ⛔ | | 38289380 | Single-cell RNA sequencing reveals cellular dynamics and therapeutic effects of astragaloside IV in slow transit constipation |
| Fennel Essential Oil | 📋 | ✍ | ⛔ | | 34725578 | Efficacy of Natural Formulation Containing Activated Charcoal, Calcium Sennosides, Peppermint Oil, Fennel Oil, Rhubarb Extract, and Purified Sulfur (Nucarb®) in Relieving Constipation |
| Fruits | 📋 | | | | 37905980 | Systematic review and meta-analysis: Foods, drinks and diets and their effect on chronic constipation in adults |
| Ginger extract | 📋 | ✍ | ⛔ | | 33241234 | Modulation of gut microbiota and intestinal barrier function during alleviation of antibiotic-associated diarrhea with Rhizoma Zingiber officinale (Ginger) extract |
| Guava | 📋 | | ⛔ | | 34634977 | Psidium guajava leaf extract improves gastrointestinal functions in rats and rabbits: an implication for ulcer and diarrhoea management |
| L-Glutamine | 📋 | ✍ | ⛔ | | 37108383 | Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model |
| Magnesium | 📋 | ✍ | ⛔ | | 37243443 | The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials |
| Caraway Essential Oil | 📋 | | ⛔ | | 31827561 | A Combination of Peppermint Oil and Caraway Oil for the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis |
| Fiber | 📋 | ✍ | ⛔ | | 37764853 | The Effect of Polyphenols, Minerals, Fibers, and Fruits on Irritable Bowel Syndrome: A Systematic Review |
| Ginseng | 📋 | ✍ | ⛔ | | 36827387 | Effect of Panax ginseng and Fructus Mume on Intestinal Barrier and Gut Microbiota in Rats with Diarrhea |
| Inulin | 📋 | ✍ | ⛔ | | 38149073 | Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study |
| Quercetin | 📋 | ✍ | ⛔ | | 34873406 | Quercetin Improves Mitochondrial Function and Inflammation in H 2 O 2-Induced Oxidative Stress Damage in the Gastric Mucosal Epithelial Cell by Regulating the PI3K/AKT Signaling Pathway |
| Turmeric | 📋 | ✍ | ⛔ | | 36447978 | Turmeric for Treatment of Irritable Bowel Syndrome: A Systematic Review of Population-Based Evidence |
| Anise | 📋 | ✍ | ⛔ | | 27815079 | Efficacy and safety of enteric coated capsules of anise oil to treat irritable bowel syndrome |
| Asafoetida | 📋 | ✍ | ⛔ | | 31277639 | Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying |
| Butyrate | 📋 | | ⛔ | | 38146566 | Effectiveness of the Combination of Probiotic Supplementation on Motor Symptoms and Constipation in Parkinson's Disease |
| Caffeine | 📋 | ✍ | ⛔ | | 38167025 | Exploring the connection between caffeine intake and constipation: a cross-sectional study using national health and nutrition examination survey data |
| Cinnamon | 📋 | ✍ | ⛔ | | 36699075 | Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 35558999 | Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial |
| Fucoidan | 📋 | ✍ | ⛔ | | 37377021 | The regulatory effects of fucoidan and laminarin on functional dyspepsia mice induced by loperamide |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 35693751 | Grape seed powder increases gastrointestinal motility |
| Hawthorn | 📋 | ✍ | ⛔ | | 34710267 | Digestion-Promoting Effects and Mechanisms of Dashanzha Pill Based on Raw and Charred Crataegi Fructus |
| Luteolin | 📋 | ✍ | ⛔ | | 38037466 | Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway |
| Micronutrients | 📋 | | ⛔ | | 37630852 | Nutrition, Physical Activity and Supplementation in Irritable Bowel Syndrome |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 38192287 | Moringa oleifera leaf alleviates functional constipation via regulating the gut microbiota and the enteric nervous system in mice |
| Mulberry | 📋 | | ⛔ | | 30785176 | Protective effect of mulberry (Morus atropurpurea) fruit against diphenoxylate-induced constipation in mice through the modulation of gut microbiota |
| Myrtle | 📋 | ✍ | ⛔ | | 28183311 | Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 31916648 | The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study |
| Paeoniflorin | 📋 | | | | 38634140 | Activation of ASIC3/ERK pathway by paeoniflorin improves intestinal fluid metabolism and visceral sensitivity in slow transit constipated rats |
| Pectin | 📋 | ✍ | ⛔ | | 35143346 | Extraction of Pectin from Orange Peel and Study of Its Protective Effect Against Loperamide-Induced Impaired Gastrointestinal Motor Functions and Oxidative Stress in Rats |
| Plum | 📋 | | ⛔ | | 35971232 | Prune juice containing sorbitol, pectin, and polyphenol ameliorates subjective complaints and hard feces while normalizing stool in chronic constipation: A randomized placebo-controlled trial |
| Prebiotics | 📋 | ✍ | ⛔ | | 36570175 | Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence |
| Resveratrol | 📋 | ✍ | ⛔ | | 37660064 | Resveratrol alleviates DSS-induced IBD in mice by regulating the intestinal microbiota-macrophage-arginine metabolism axis |
| Valerian Root | 📋 | ✍ | ⛔ | | 35863616 | Antidiarrheal activity of the extracts of Valeriana jatamansi Jones on castor oil-induced diarrhea mouse by regulating multiple signal pathways |
| Activated Charcoal | 📋 | ✍ | ⛔ | | 36132707 | Dose-dependent Action of Zingiber officinale on Colonic Dysmotility and Ex Vivo Spontaneous Intestinal Contraction Modulation |
| Ashwagandha | 📋 | ✍ | ⛔ | | 37543151 | A blend of Withania somnifera (L.) Dunal root and Abelmoschus esculentus (L.) Moench fruit extracts relieves constipation and improves bowel function: A proof-of-concept clinical investigation |
| Balloon Flower | 📋 | ✍ | ⛔ | | 36992686 | Improvement of loperamide-hydrochloride-induced intestinal motility disturbance by Platycodon grandiflorum polysaccharides through effects on gut microbes and colonic serotonin |
| Bee Propolis | 📋 | ✍ | ⛔ | | 35702280 | Effects of propolis supplementation on irritable bowel syndrome with constipation (IBS-C) and mixed (IBS-M) stool pattern: A randomized, double-blind clinical trial |
| Black Tea | 📋 | ✍ | ⛔ | | 27324724 | The Effect of Black Tea (Camellia sinensis (L) Kuntze) on Pediatrics With Acute Nonbacterial Diarrhea: A Randomized Controlled Trial |
| Cannabidiol | 📋 | ✍ | ⛔ | | 32357565 | Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals? |
| Chamomile | 📋 | ✍ | ⛔ | | 36559534 | Myrrh and Chamomile Flower Extract Inhibit Mediator Release from IgE-stimulated Mast-Cell-Like RBL-2H3 Cells |
| Choline | 📋 | ✍ | ⛔ | | 35456341 | Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation-Randomized Case-Control Study |
| Coffee | 📋 | ✍ | ⛔ | | 36882107 | Coffee and tea intake with long-term risk of irritable bowel syndrome: a large-scale prospective cohort study |
| Dioscin | 📋 | | | | 36246057 | Dioscin ameliorates slow transit constipation in mice by up-regulation of the BMP2 secreted by muscularis macrophages |
| Flaxseed | 📋 | ✍ | ⛔ | | 36299564 | Influence of Flax Seeds on the Gut Microbiota of Elderly Patients with Constipation |
| Frankincense | 📋 | ✍ | ⛔ | | 35276778 | Beneficial Effects on Abdominal Bloating with an Innovative Food-Grade Formulation of Curcuma longa and Boswellia serrata Extracts in Subjects with Irritable Bowel Syndrome and Small Bowel Dysbiosis |
| Gingerol | 📋 | ✍ | | | 35704960 | Efficacy and safety of a food supplement with standardized menthol, limonene, and gingerol content in patients with irritable bowel syndrome: A double-blind, randomized, placebo-controlled trial |
| Hesperidin | 📋 | ✍ | ⛔ | | 36034863 | Hesperidin promotes gastric motility in rats with functional dyspepsia by regulating Drp1-mediated ICC mitophagy |
| Honey | 📋 | ✍ | ⛔ | | 34724778 | The Effect of Adding Honey to Zinc in the Treatment of Diarrhea in Children |
| Lemon Balm | 📋 | ✍ | ⛔ | | 29879761 | The Protective Effect of Melissa officinalis L. in Visceral Hypersensitivity in Rat Using 2 Models of Acid-induced Colitis and Stress-induced Irritable Bowel Syndrome: A Possible Role of Nitric Oxide Pathway |
| Licorice Root | 📋 | ✍ | ⛔ | | 35997860 | Ethanol Extract of Glycyrrhiza uralensis Fisch: Antidiarrheal Activity in Mice and Contraction Effect in Isolated Rabbit Jejunum |
| Marjoram | 📋 | | ⛔ | | 38420828 | Calcium Channel Inhibitory Effect of Marjoram ( Origanum majorana L.): Its Medicinal Use in Diarrhea and Gut Hyperactivity |
| Milk Thistle | 📋 | ✍ | ⛔ | | 31277639 | Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying |
| Neroli Essential Oil | 📋 | ✍ | ⛔ | | 35087623 | Transdermal Administration of Volatile Oil from Citrus aurantium- Rhizoma Atractylodis Macrocephalae Alleviates Constipation in Rats by Altering Host Metabolome and Intestinal Microbiota Composition |
| Olive Oil | 📋 | ✍ | ⛔ | | 34981493 | Evaluation of the Anti-constipation Effects of Abdominal Application of Olive Oil Ointment in Children 1-4 Years Old: A Pilot Placebo-Controlled, Double-Blind, Randomized Clinical Trial |
| Peony | 📋 | | ⛔ | | 38186470 | Atractylodes macrocephala-Paeonia lactiflora Class Formula for the Treatment of Irritable Bowel Syndrome: A Systematic Review With Meta-Analysis and Trial Sequential Analysis |
| Perilla | 📋 | ✍ | | | 35705194 | Effect of 8-week intake of the omega-3 fatty acid-rich perilla oil on the gut function and as a fuel source for female athletes: A randomised trial |
| Piperine | 📋 | ✍ | ⛔ | | 38158111 | Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies |
| Polyphenols | 📋 | | | | 37764853 | The Effect of Polyphenols, Minerals, Fibers, and Fruits on Irritable Bowel Syndrome: A Systematic Review |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 32560291 | Pomegranate Mesocarp Against Colitis-Induced Visceral Pain in Rats: Effects of a Decoction and Its Fractions |
| Poria Mushrooms | 📋 | ✍ | | | 37628079 | Water-Insoluble Polysaccharide Extracted from Poria cocos Alleviates Antibiotic-Associated Diarrhea Based on Regulating the Gut Microbiota in Mice |
| Pterostilbene | 📋 | ✍ | ⛔ | | 35652049 | Based on Network Pharmacology and Gut Microbiota Analysis to Investigate the Mechanism of the Laxative Effect of Pterostilbene on Loperamide-Induced Slow Transit Constipation in Mice |
| Puerarin | 📋 | ✍ | ⛔ | | 33595580 | Puerarin from Pueraria lobata alleviates the symptoms of irritable bowel syndrome-diarrhea |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 31894044 | Evaluation of prokinetic and laxative effects of Hippophae rhamnoides in rodents |
| Silymarin | 📋 | ✍ | ⛔ | | 35456341 | Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation-Randomized Case-Control Study |
| Tea | 📋 | | | | 36882107 | Coffee and tea intake with long-term risk of irritable bowel syndrome: a large-scale prospective cohort study |
| Wogonin | 📋 | ✍ | ⛔ | | 31105793 | Anti-diarrheal effect of Scutellaria baicalensis is associated with suppression of smooth muscle in the rat colon |
| Zingerone | 📋 | | | | 24262066 | Zingerone regulates intestinal transit, attenuates behavioral and oxidative perturbations in irritable bowel disorder in rats |
| 5-HTP | 📋 | ✍ | ⛔ | | 31071306 | Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression |
| Acacetin | 📋 | | | | 34594156 | The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis |
| Almond Oil | 📋 | | ⛔ | | 35774276 | Comparison of the Effects of Abdominal Massage and Oral Administration of Sweet Almond Oil on Constipation and Quality of Life among Elderly Individuals: A Single-Blind Clinical Trial |
| Anethole | 📋 | | | | 26915803 | Anethole restores delayed gastric emptying and impaired gastric accommodation in rodents |
| Apigenin | 📋 | ✍ | ⛔ | | 37801900 | Apigenin attenuates visceral hypersensitivity in water avoidance stress rats by modulating the microbiota-gut-brain axis and inhibiting mast cell activation |
| Apple | 📋 | | ⛔ | | 37129213 | Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 34803538 | Naturopathic Approach to Functional Dyspepsia: A Case Report |
| Arctiin | 📋 | | | | 37090075 | Arctiin alleviates functional constipation by enhancing intestinal motility in mice |
| Astaxanthin | 📋 | ✍ | ⛔ | | 35635517 | Astaxanthin attenuated the stress-induced intestinal motility disorder via altering the gut microbiota |
| Astragalus Root | 📋 | ✍ | ⛔ | | 36205566 | Astragalus Polysaccharide Alleviates Constipation in the Elderly via Modification of Gut Microbiota and Fecal Metabolism |
| Avocado | 📋 | ✍ | ⛔ | | 25237361 | Acute Toxicity Investigation and Anti-diarrhoeal Effect of the Chloroform-Methanol Extract of the Leaves of Persea americana |
| Banana | 📋 | | ⛔ | | 36692306 | Role of cooked green banana in home management of acute diarrhea in under-5 children |
| Bay Leaf | 📋 | | ⛔ | | 22082096 | Antidiarrheal activity of Laurus nobilis L. leaf extract in rats |
| Bitter Melon | 📋 | ✍ | ⛔ | | 35527657 | Momordica charantia polysaccharides alleviate diarrhea-predominant irritable bowel syndrome by regulating intestinal inflammation and barrier via NF-κB pathway |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 30676012 | Oral administration of a lecithin-based delivery form of boswellic acids (Casperome®) for the prevention of symptoms of irritable bowel syndrome: a randomized clinical study |
| Buckwheat | 📋 | | ⛔ | | 23365604 | In Vivo and In Vitro Antinociceptive Effect of Fagopyrum cymosum (Trev.) Meisn Extracts: A Possible Action by Recovering Intestinal Barrier Dysfunction |
| Burdock | 📋 | | ⛔ | | 30981336 | Structural characterization and rheological properties of a pectin with anti-constipation activity from the roots of Arctium lappa L |
| Camellia | 📋 | | ⛔ | | 35178105 | Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition |
| Cantaloupe | 📋 | | ⛔ | | 36773554 | Mechanistic insights of Cucumis melo L. seeds for gastrointestinal muscle spasms through calcium signaling pathway-related gene regulation networks in WGCNA and in vitro, in vivo studies |
| Capsaicin | 📋 | ✍ | ⛔ | | 21918995 | Fat Digestion and Absorption in Spice-Pretreated Rats |
| Caraway | 📋 | | ⛔ | | 35255832 | A novel duodenal-release formulation of caraway oil and L-menthol is a safe, effective and well tolerated therapy for functional dyspepsia |
| Carotenoids | 📋 | ✍ | ⛔ | | 37608273 | Association between dietary carotenoids intake and chronic constipation in American men and women adults: a cross-sectional study |
| Cashew | 📋 | | ⛔ | | 35028183 | Evaluation of the gastrointestinal anti-motility effect of Anacardium occidentale stem bark extract: A mechanistic study of antidiarrheal activity |
| Chitosan | 📋 | ✍ | ⛔ | | 36889616 | Integrating omics and network pharmacology reveals the anti-constipation role of chitosan with different molecular weights in constipated mice |
| Chlorella | 📋 | ✍ | ⛔ | | 38268875 | The effect of Chlorella supplementation in pregnant women with low-grade inflammation |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 37616338 | Chlorogenic Acid Ameliorates Post-Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes |
| Cinnamaldehyde | 📋 | | | | 33761597 | Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice |
| Cocoa | 📋 | ✍ | ⛔ | | 30716903 | Laxative effect of probiotic chocolate on loperamide-induced constipation in rats |
| Coconut Oil | 📋 | | ⛔ | | 37513952 | Probiotic Formulations Containing Fixed and Essential Oils Ameliorates SIBO-Induced Gut Dysbiosis in Rats |
| Collagen | 📋 | ✍ | | | 35639457 | Effect of a Daily Collagen Peptide Supplement on Digestive Symptoms in Healthy Women: 2-Phase Mixed Methods Study |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 33427835 | Evidence from comparative genomic analyses indicating that Lactobacillus-mediated irritable bowel syndrome alleviation is mediated by conjugated linoleic acid synthesis |
| Copper | 📋 | ✍ | ⛔ | | 34132328 | The Role of Copper and Zinc in Irritable Bowel Syndrome: A Mendelian Randomization Study |
| Coptis Chinensis | 📋 | | ⛔ | | 21511022 | Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome |
| Coriander | 📋 | | ⛔ | | 16868824 | The Efficacy of an Herbal Medicine, Carmint, on the Relief of Abdominal Pain and Bloating in Patients With Irritable Bowel Syndrome: A Pilot Study |
| Cucumber | 📋 | | ⛔ | | 34832981 | Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway |
| D-Limonene | 📋 | ✍ | ⛔ | | 35704960 | Efficacy and safety of a food supplement with standardized menthol, limonene, and gingerol content in patients with irritable bowel syndrome: A double-blind, randomized, placebo-controlled trial |
| Daidzein | 📋 | ✍ | ⛔ | | 36558058 | Daidzein Protects Caco-2 Cells against Lipopolysaccharide-Induced Intestinal Epithelial Barrier Injury by Suppressing PI3K/AKT and P38 Pathways |
| Dandelion | 📋 | ✍ | ⛔ | | 20485248 | [Phytotherapy with a mixture of dry extracts with hepato-protective effects containing artichoke leaves in the management of functional dyspepsia symptoms] |
| Date | 📋 | | ⛔ | | 24611963 | Effects of dates pulp extract and palm sap (Phoenix dactylifera L.) on gastrointestinal transit activity in healthy rats |
| Diallyl Trisulfide | 📋 | | | | 30098911 | Diallyl trisulfide regulates rat colonic smooth muscle contractions by inhibiting L-type calcium channel currents |
| Elderberry | 📋 | ✍ | ⛔ | | 36877342 | Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome |
| Emodin | 📋 | | ⛔ | | 34828045 | Emodin Improves Intestinal Health and Immunity through Modulation of Gut Microbiota in Mice Infected by Pathogenic Escherichia coli O 1 |
| Essential Oils | 📋 | | ⛔ | | 24283351 | Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome |
| Eugenol | 📋 | | | | 25473818 | Protective effect of eugenol against restraint stress-induced gastrointestinal dysfunction: Potential use in irritable bowel syndrome |
| Fennel | 📋 | ✍ | ⛔ | | 32682507 | Heated fennel therapy promotes the recovery of gastrointestinal function in patients after complex abdominal surgery: A single-center prospective randomized controlled trial in China |
| Fermented Foods | 📋 | | ⛔ | | 37181929 | Fermented Vegetables as a Potential Treatment for Irritable Bowel Syndrome |
| Fig | 📋 | | ⛔ | | 27440682 | Randomized, double-blind, placebo-controlled trial of Ficus carica paste for the management of functional constipation |
| Fisetin | 📋 | ✍ | ⛔ | | 38163954 | Fisetin Treats Kidney Oxidative Stress, Inflammation, and Apoptosis in Rat Diarrhea |
| Galangal | 📋 | ✍ | ⛔ | | 37664921 | Exploring the Underlying Mechanism of Alpinia officinarum Hance Ameliorating Diabetic Gastroparesis through Combining Network Pharmacology, Molecular Docking, and in Vivo Experimental Verification |
| Garlic | 📋 | ✍ | ⛔ | | 36721177 | Garlic supplementation improves intestinal transit time, lipid accumulation product and cardiometabolic indices in subjects with metabolic syndrome: A randomized controlled trial |
| Geraniol | 📋 | | | | 36235860 | Geraniol Treatment for Irritable Bowel Syndrome: A Double-Blind Randomized Clinical Trial |
| Ginger Essential Oil | 📋 | ✍ | | | 36058824 | "Effects of abdominal massage applied with ginger and lavender oil for elderly with constipation: A randomized controlled trial" |
| Glucosamine | 📋 | ✍ | ⛔ | | 34202877 | Impact of Glucosamine Supplementation on Gut Health |
| Goji Berry | 📋 | ✍ | ⛔ | | 32285052 | Dietary Intake of Lycium Ruthenicum Murray Ethanol Extract Inhibits Colonic Inflammation in Dextran Sulfate Sodium-Induced Murine Experimental Colitis |
| Grape | 📋 | | ⛔ | | 32392768 | Potent In Vitro Activity of Citrus aurantium Essential Oil and Vitis vinifera Hydrolate Against Gut Yeast Isolates from Irritable Bowel Syndrome Patients-The Right Mix for Potential Therapeutic Use |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 37085597 | Green tea extract prevents CPT-11-induced diarrhea by regulating the gut microbiota |
| Honokiol | 📋 | | | | 35157953 | Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle |
| Indian Gooseberry | 📋 | | ⛔ | | 35627061 | Aqueous Extract of Phyllanthus emblica L. Alleviates Functional Dyspepsia through Regulating Gastrointestinal Hormones and Gut Microbiome In Vivo |
| Isoliquiritigenin | 📋 | | | | 38325854 | Efficacy of Glycicumarin and Isoliquiritigenin in Suppressing Colonic Peristalsis in Both an Animal Model and a Clinical Trial |
| Kale | 📋 | | | | 38094924 | Kale improves bowel movements in constipated women and affects some intestinal microbes and metabolites: a pilot study |
| Kombucha | 📋 | ✍ | ⛔ | | 38149073 | Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study |
| L-Lysine | 📋 | ✍ | ⛔ | | 20720257 | Effect of Lysine Supplementation on Health and Morbidity in Subjects Belonging to Poor Peri-Urban Households in Accra, Ghana |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 38613060 | A Low FODMAP Diet Supplemented with L-Tryptophan Reduces the Symptoms of Functional Constipation in Elderly Patients |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 36058824 | "Effects of abdominal massage applied with ginger and lavender oil for elderly with constipation: A randomized controlled trial" |
| Lemon | 📋 | | ⛔ | | 35013789 | Glycemic response, satiety, gastric secretions and emptying after bread consumption with water, tea or lemon juice: a randomized crossover intervention using MRI |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 37513952 | Probiotic Formulations Containing Fixed and Essential Oils Ameliorates SIBO-Induced Gut Dysbiosis in Rats |
| Lipase | 📋 | ✍ | ⛔ | | 25287168 | Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects |
| Lutein | 📋 | ✍ | ⛔ | | 30641888 | Intake of Lutein and Zeaxanthin as a Possible Factor Influencing Gastrointestinal Symptoms in Caucasian Individuals with Ulcerative Colitis in Remission Phase |
| Lycopene | 📋 | ✍ | ⛔ | | 37608273 | Association between dietary carotenoids intake and chronic constipation in American men and women adults: a cross-sectional study |
| Magnolol | 📋 | | | | 35157953 | Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle |
| Mango Leaf | 📋 | | ⛔ | | 25575467 | Antidiarrhoeal activity of aqueous extract of Mangifera indica L. leaves in female albino rats |
| Millet | 📋 | | | | 36071942 | Alteration of intestinal microflora by the intake of millet porridge improves gastrointestinal motility |
| Minerals | 📋 | | | | 37764853 | The Effect of Polyphenols, Minerals, Fibers, and Fruits on Irritable Bowel Syndrome: A Systematic Review |
| Myrrh | 📋 | ✍ | ⛔ | | 36559534 | Myrrh and Chamomile Flower Extract Inhibit Mediator Release from IgE-stimulated Mast-Cell-Like RBL-2H3 Cells |
| Naringenin | 📋 | ✍ | ⛔ | | 29207043 | Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation |
| NMN | 📋 | ✍ | ⛔ | | 29263919 | Nicotinamide adenine dinucleotide replenishment rescues colon degeneration in aged mice |
| Nobiletin | 📋 | ✍ | | | 38387277 | Nobiletin, an active component of Wenyang Yiqi formula, alleviates constipation associated depression through targeting MAPT to inhibit the MAPK signaling pathway |
| Noni | 📋 | | ⛔ | | 38144717 | Constituent analysis, laxative activity, and toxicological evaluation of methanol extract of noni fruit ( Morinda citrifolia L., Rubiaceae) |
| Okra | 📋 | | ⛔ | | 37543151 | A blend of Withania somnifera (L.) Dunal root and Abelmoschus esculentus (L.) Moench fruit extracts relieves constipation and improves bowel function: A proof-of-concept clinical investigation |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 35276825 | Olea europea L. Leaves and Hibiscus sabdariffa L. Petals Extracts: Herbal Mix from Cardiovascular Network Target to Gut Motility Dysfunction Application |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 37108383 | Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model |
| Paeonol | 📋 | | | | 36358984 | Beneficial Effect of Paeonol on Antibiotic-Associated Inflammatory Response in Mice with Diarrhea |
| Papain | 📋 | ✍ | ⛔ | | 33710722 | Region-specific effects of the cysteine protease papain on gastric motility |
| Peach | 📋 | | ⛔ | | 37064951 | Molecular Mechanism of the Therapeutic Effect of Peach Blossom against Constipation: An Exploratory Study Based on Network Pharmacology Analysis and Molecular Docking Verification |
| Persimmon | 📋 | | ⛔ | | 33872072 | Antidiarrheal, Antimicrobial, and Antioxidant Properties of the Aqueous Extract of Tunisian Persimmon ( Diospyros kaki Thunb.) Fruits |
| Phytochemicals | 📋 | | | | 37739651 | Dietary intake of phytochemicals in association with irritable bowel syndrome in adults |
| Pine Bark | 📋 | ✍ | ⛔ | | 29737150 | Pycnogenol® supplementation improves the control of irritable bowel syndrome symptoms |
| Prickly Pear | 📋 | | ⛔ | | 32935904 | Nopal fiber (Opuntia ficus-indica) improves symptoms in irritable bowel syndrome in the short term: a randomized controlled trial |
| Procyanidins | 📋 | | ⛔ | | 21534629 | Dietary grape-seed procyanidins decreased postweaning diarrhea by modulating intestinal permeability and suppressing oxidative stress in rats |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 24604453 | Component analysis of Pu-erh and its anti-constipation effects |
| Rehmannia | 📋 | ✍ | ⛔ | | 34335262 | Aucuboside Inhibits the Generation of Th17 Cells in Mice Colitis |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 25830061 | Ganoderma Lucidum Pharmacopuncture for Teating Ethanol-induced Chronic Gastric Ulcers in Rats |
| Rose | 📋 | | | | 35963416 | Rosa damascena together with brown sugar mitigate functional constipation in children over 12 months old: A double-blind randomized controlled trial |
| Roselle | 📋 | ✍ | ⛔ | | 35276825 | Olea europea L. Leaves and Hibiscus sabdariffa L. Petals Extracts: Herbal Mix from Cardiovascular Network Target to Gut Motility Dysfunction Application |
| Rosemary | 📋 | ✍ | ⛔ | | 20485248 | [Phytotherapy with a mixture of dry extracts with hepato-protective effects containing artichoke leaves in the management of functional dyspepsia symptoms] |
| Rye | 📋 | | ⛔ | | 37905980 | Systematic review and meta-analysis: Foods, drinks and diets and their effect on chronic constipation in adults |
| Saffron | 📋 | ✍ | ⛔ | | 38146566 | Effectiveness of the Combination of Probiotic Supplementation on Motor Symptoms and Constipation in Parkinson's Disease |
| Selenium | 📋 | ✍ | ⛔ | | 33095434 | Association Between Selenium Intake with Chronic Constipation and Chronic Diarrhea in Adults: Findings from the National Health and Nutrition Examination Survey |
| Sesame | 📋 | ✍ | ⛔ | | 35510626 | Evaluation of the effect of prebiotic sesame candies on loperamide-induced constipation in mice |
| Shogaol | 📋 | | | | 31367349 | Pharmacological effects of different ginger juices on the concurrent symptoms in animal models of functional dyspepsia: A comparative study |
| Skullcap | 📋 | ✍ | ⛔ | | 31105793 | Anti-diarrheal effect of Scutellaria baicalensis is associated with suppression of smooth muscle in the rat colon |
| Spearmint | 📋 | | ⛔ | | 16868824 | The Efficacy of an Herbal Medicine, Carmint, on the Relief of Abdominal Pain and Bloating in Patients With Irritable Bowel Syndrome: A Pilot Study |
| Spirulina | 📋 | ✍ | ⛔ | | 31054300 | Polysaccharide from Spirulina platensis ameliorates diphenoxylate-induced constipation symptoms in mice |
| Sugarcane | 📋 | | ⛔ | | 30946967 | A randomized controlled double blinded trial to evaluate efficacy of oral administration of black strap molasses (sugarcane extract) in comparison with polyethylene glycol on pediatric functional constipation |
| Sulfur | 📋 | ✍ | ⛔ | | 34725578 | Efficacy of Natural Formulation Containing Activated Charcoal, Calcium Sennosides, Peppermint Oil, Fennel Oil, Rhubarb Extract, and Purified Sulfur (Nucarb®) in Relieving Constipation |
| Tangeretin | 📋 | | | | 25451794 | Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin |
| Thymoquinone | 📋 | | ⛔ | | 22768141 | Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors |
| Vitamin A | 📋 | ✍ | ⛔ | | 10390287 | The beneficial effects of weekly low-dose vitamin A supplementation on acute lower respiratory infections and diarrhea in Ecuadorian children |
| Vitamin B Complex | 📋 | | ⛔ | | 38149073 | Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 31960952 | Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients |
| Vitamin C | 📋 | ✍ | ⛔ | | 24239723 | Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach |
| Vitamins | 📋 | | | | 37260904 | Vitamin D improves irritable bowel syndrome symptoms: A meta-analysis |
| Wormwood | 📋 | ✍ | ⛔ | | 33281909 | Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats |
| Yogurt | 📋 | | ⛔ | | 35576292 | Comparison Of Efficacy Of Yogurt Versus Probiotics For The Management Of Acute Diarrhoea |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 30641888 | Intake of Lutein and Zeaxanthin as a Possible Factor Influencing Gastrointestinal Symptoms in Caucasian Individuals with Ulcerative Colitis in Remission Phase |
